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KMID : 0360319930250060920
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Journal of Korean Cancer Research Association
1993 Volume.25 No. 6 p.920 ~ p.927
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Correlation of Tumor Angiogenesis and Lymph Node Metastasis in Invasive Breast Carcinoma
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Abstract
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Angiogenesis is a process of generating new capillary blood vessels and leads to neovascularization, which is related to the growth of solid tumor and metastasis. A tumor must stimulate the growth of new capillary blood vessels for tumor itself
to
grow.
Futhermore, the new blood vessels embedded in a tumor provide a gateway for tumor cells to enter the circulation and to metastasize to distant sites.
To investigate how tumor angiogenesis correlate with metastases in breast carcinoma, we counted the number of microvessels including venule, arteriole and capillaries(per×200 field) within the tumor of 92 cases(47 with metastasis and 45
without).
We
have also analysed relationship between lymph node metastasis and other estabilished prognostic factors. The risk of metastasis is increased in proportion as a number of microvessel within tumor increases: relative risk of node metastasis in
group
with
highest number of microvessels(above 54/X200PF) is 87.75 fold compaired to group with lowest number of microvessels(under 36/X200PF) (p value <0.001). This result support that the number of microvessels mostly composed of neovessels within tumor
is
strongly correlated with lymph node metastasis. This study also shows that group with larger tumor size and lower Black's nuclear grade has a tendency to have high risk of metastasis, although statistically not significant. Patient's age,
Bloom-Richardson grade and estrogen receptor status do not show significant association with node metastasis.
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KEYWORD
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